Immunohistochemical features of the collagen’ formation in the uterus of fetuses with a gestational term of 21-28 weeks from mothers, whose pregnancy was complicated by preeclampsia of different stage of severity

In the following article we are going to provide results of research on uterus’ structure in case fetuses with a gestational term 21-28 weeks from mothers, whose pregnancy was complicated by PE different severity stage (15 cases) comparing one mothers physiological cases). All have died intranatally as result an acute disorder uterine-placental and uterine-fetal circulation. The methods: macroscopic, organometric, histological, immunohistochemical, morphometric statictical. By applying organometric method revealed probable decrease indexes weight, length thickness uterine’ wall ones healthy mothers. observative histological had not any significant changes strucutre organs’ study groups. Thus, all organs were represented mucous, muscular serous membranes clear boundary between them. comparative features PE. structural components organ’s clearly decreased pregnancy. uterine endometrium moderate proliferative (hormonal) activity taking place, however, meanwhile, severe could notice glands’ number well lack them (hypoplastic changes). immunohistochemical using MCAT CD 95 disclosed increase apoptotic index towards Among specific myometrium name ones: vascular component percentage growth connective tissue. Moreover, tissue is mostly collagen III type, while, I type prevails. walls vessels arterial uterus increased glow IV type. However, increse There fact, which attracts attention it. Namely, aforementioned minimally manifested, when mild course disease took maximally manifested one. severity, that postulated above, contribute formation glanduar hyperplasia, endometrial polyps, precancerous diseases cancer subsequent ontogenesis, it lead impaired infertility. connected bed mother-placenta-fetus system endocrine disorders, take place this pathology, organism pregnant woman.